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肌瘤假包膜中神经纤维的免疫组织化学定位

Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids.

作者信息

Sun Y, Zhu L, Huang X, Zhou C, Zhang X

机构信息

Hebei Province General Hospital.

出版信息

Eur J Histochem. 2014 May 8;58(2):2249. doi: 10.4081/ejh.2014.2249.

DOI:10.4081/ejh.2014.2249
PMID:24998917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4083317/
Abstract

The pseudocapsule surrounding fibroids consists of compressed myometrium containing nerves and blood vessels that continue into adjacent myometrium. Oxytocin (OXT) is thought to affect wound healing after myomectomy. We determined the presence of OXT and protein gene product 9.5 (PGP9.5) immunoreactive nerve fibers in pseudocapsule compared to adjacent myometrium. Samples (N=106) of pseudocapsule and adjacent myometrium were collected from 57 women with uterine fibroids undergoing myomectomy, and stained with anti-OXT and PGP 9.5 antibodies to demonstrate the presence of nerve fibers. Nerve fibers in the pseudocapsule stained positively with OXT (89/106, 84.0%) and PGP 9.5 (94/106, 88.7%). The densities of nerve fibers staining with PGP 9.5 and OXT in the pseudocapsule were highest in the isthmus (23.68±22.45/mm2 and 43.35±40.74/mm2, respectively). There were no significant differences in the density of nerve fibers, stained with either OXT or PGP 9.5, between the pseudocapsule, and adjacent normal myometrium regardless of the fibroid location in the uterus (P>0.05). These results suggest that the pseudocapsule should avoid to be damaged during the myomectomy procedure.

摘要

子宫肌瘤周围的假包膜由包含神经和血管的受压肌层组成，这些神经和血管会延伸至相邻的肌层。催产素（OXT）被认为会影响子宫肌瘤切除术后的伤口愈合。我们比较了假包膜与相邻肌层中OXT和蛋白基因产物9.5（PGP9.5）免疫反应性神经纤维的存在情况。从57例行子宫肌瘤切除术的子宫肌瘤患者中收集假包膜和相邻肌层的样本（N = 106），并用抗OXT和PGP 9.5抗体染色以显示神经纤维的存在。假包膜中的神经纤维对OXT呈阳性染色（89/106，84.0%），对PGP 9.5呈阳性染色（94/106，88.7%）。假包膜中PGP 9.5和OXT染色的神经纤维密度在峡部最高（分别为23.68±22.45/mm²和43.35±40.74/mm²）。无论肌瘤在子宫中的位置如何，假包膜与相邻正常肌层中OXT或PGP 9.5染色的神经纤维密度均无显著差异（P>0.05）。这些结果表明，在子宫肌瘤切除术中应避免损伤假包膜。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/b7f849423fad/ejh-2014-2-2249-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/ca666d8f8995/ejh-2014-2-2249-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/8a2e613aaea7/ejh-2014-2-2249-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/8e48f1844fb0/ejh-2014-2-2249-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/b7f849423fad/ejh-2014-2-2249-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/ca666d8f8995/ejh-2014-2-2249-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/8a2e613aaea7/ejh-2014-2-2249-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/8e48f1844fb0/ejh-2014-2-2249-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e961/4083317/b7f849423fad/ejh-2014-2-2249-g004.jpg

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本文引用的文献

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Oxytocin modulates mTORC1 pathway in the gut.催产素调节肠道中的 mTORC1 通路。
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The interaction between the oxytocin and pain modulation in headache patients.头痛患者中催产素与疼痛调节的相互作用。
自主神经支配与子宫肌瘤形成中的子宫间质细胞相互作用。
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