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动物病毒对膜通透性的改变

Modification of membrane permeability by animal viruses.

作者信息

Carrasco L, Otero M J, Castrillo J L

机构信息

Departamento de Microbiología, Universidad Autónoma and Consejo Superior de Investigaciones Científicas, Madrid, Spain.

出版信息

Pharmacol Ther. 1989;40(2):171-212. doi: 10.1016/0163-7258(89)90096-x.

Abstract

Animal viruses modify membrane permeability during lytic infection. There is a co-entry of macromolecules and virion particules during virus penetration and a drastic change in transport and membrane permeability at the late stages of the lytic cycle. Both events are of importance to understand different molecular aspects of viral infection, as virus entry into the cell and the interference of virus infection with cellular metabolism. Other methods of cell permeabilization of potential relevance to understand the mechanism of viral damage of the membrane are also discussed.

摘要

动物病毒在裂解感染过程中会改变膜通透性。在病毒穿透过程中,大分子和病毒粒子会共同进入细胞,并且在裂解周期后期,运输和膜通透性会发生剧烈变化。这两个事件对于理解病毒感染的不同分子层面非常重要,比如病毒进入细胞以及病毒感染对细胞代谢的干扰。本文还讨论了其他可能与理解病毒对膜损伤机制相关的细胞通透化方法。

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