Claros-Salinas Dolores, Greitemann Georg, Hassa Thomas, Nedelko Violetta, Steppacher Inga, Harris Joseph Allen, Schoenfeld Mircea Ariel
Kliniken Schmieder Konstanz, Germany Lurija Institut Konstanz, Germany.
Lurija Institut Konstanz, Germany Kliniken Schmieder Allensbach, Germany.
Restor Neurol Neurosci. 2014;32(4):463-72. doi: 10.3233/RNN-130342.
The loss of calculation skills due to brain lesions leads to a major reduction in the quality of life and is often associated with difficulties of returning to work and a normal life. Very little is known about the neural mechanisms underlying performance improvement due to calculation training during rehabilitation. The current study investigates the neural basis of training-induced changes in patients with acalculia following ischemic stroke or traumatic brain lesions.
Functional hemodynamic responses (fMRI) were recorded in seven patients during calculation and perceptual tasks both before and after acalculia training.
Despite the heterogeneity of brain lesions associated with acalculia in our patient sample, a common pattern of training-induced changes emerged. Performance improvements were associated with widespread deactivations in the prefrontal cortex. These deactivations were calculation-specific and only observed in patients exhibiting a considerable improvement after training.
These findings suggest that the training-induced changes in our patients rely on an increase of frontal processing efficiency.
因脑损伤导致的计算技能丧失会使生活质量大幅下降，且常与重返工作岗位及正常生活的困难相关。对于康复期间计算训练导致的表现改善背后的神经机制，我们知之甚少。本研究调查了缺血性中风或创伤性脑损伤后失算症患者训练引起变化的神经基础。
在7名患者进行失算症训练前后的计算和感知任务期间，记录其功能血流动力学反应（功能磁共振成像）。
尽管我们患者样本中与失算症相关的脑损伤具有异质性，但仍出现了训练引起变化的共同模式。表现改善与前额叶皮质广泛的失活有关。这些失活是特定于计算的，且仅在训练后表现出显著改善的患者中观察到。
这些发现表明我们患者中训练引起的变化依赖于额叶处理效率的提高。
