Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
J Biol Regul Homeost Agents. 2014 Apr-Jun;28(2):177-81.
Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of FcεRI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).
人类肥大细胞（1879 年由保罗·埃尔利希首次描述）由骨髓中表达分化标志物 CD34+的定向前体细胞发育而来，与其他三种髓样细胞不同。肥大细胞存在于各种组织中，特别是在血管、上皮和神经附近，它们通过 FcεRI 的交联激活，也被许多神经肽激活。NGF 与肥大细胞的大量积累一起介导许多炎症和自身免疫状态，这些肥大细胞似乎参与神经免疫相互作用和组织炎症。在这里，我们报告了肥大细胞和神经生长因子（NGF）之间的一些关系。
