Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Department of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Keelung, Taiwan.
J Biol Regul Homeost Agents. 2014 Apr-Jun;28(2):225-36.
Vascular endothelial growth factor-B (VEGF-B is an important member of the VEGF protein family. Recent animal studies indicated that VEGF-B signaling had determinant roles in insulin resistance, lipid distribution and metabolism in type 2 diabetes. The clinical significance of VEGF-B in type 2 diabetes is still not clear. This study aimed to correlate VEGF-B levels with biochemistry characteristics and target organ damage in type 2 diabetic patients. Serum VEGF-B levels were measured using ELISA. A crosssectional control study, which included 180 type 2 diabetic patients and 62 healthy subjects, was carried out. Diabetic patients who were undergoing insulin therapy were not included. This results showed that serum VEGF-B levels did not differ between the type 2 diabetic patients and the healthy controls (169.2∓118.8 vs 163.5∓115.2 pg/mL; P=0.734). VEGF-B levels in type 2 diabetic patients were significantly associated with the levels of c-peptide, total cholesterol and triglyceride. T-test analysis showed that the associations of serum VEGF-B levels with insulin resistance, pancreatic reserve, HDL and LDL were not significant. Regression analysis showed that VEGF-B levels were significantly correlated with diabetic retinopathy and nephropathy. No significant association between VEGF-B and macro-vasculopathy was found. In conclusion, our study findings suggested that VEGF-B levels did not differ between the type 2 diabetic patients and the normal controls. High VEGF-B levels might correlate with the presence of hyperlipidemia and target organ damage in type 2 diabetic patients.
血管内皮生长因子-B（VEGF-B）是 VEGF 蛋白家族的重要成员。最近的动物研究表明，VEGF-B 信号在 2 型糖尿病中的胰岛素抵抗、脂质分布和代谢中具有决定性作用。VEGF-B 在 2 型糖尿病中的临床意义尚不清楚。本研究旨在探讨 2 型糖尿病患者中 VEGF-B 水平与生化特征和靶器官损害的相关性。采用 ELISA 法测定血清 VEGF-B 水平。进行了一项横断面对照研究，共纳入 180 例 2 型糖尿病患者和 62 例健康对照者，未纳入正在接受胰岛素治疗的糖尿病患者。结果显示，2 型糖尿病患者与健康对照组的血清 VEGF-B 水平无差异（169.2∓118.8 比 163.5∓115.2 pg/mL；P=0.734）。2 型糖尿病患者的 VEGF-B 水平与 C 肽、总胆固醇和甘油三酯水平显著相关。t 检验分析显示，血清 VEGF-B 水平与胰岛素抵抗、胰岛储备、HDL 和 LDL 之间的相关性无统计学意义。回归分析显示，VEGF-B 水平与糖尿病视网膜病变和肾病显著相关。未发现 VEGF-B 与大血管病变之间存在显著相关性。总之，本研究结果表明，2 型糖尿病患者与健康对照组的血清 VEGF-B 水平无差异。高 VEGF-B 水平可能与 2 型糖尿病患者的血脂异常和靶器官损害有关。
