Stanley Margaret A, Sudenga Staci L, Giuliano Anna R
University of Cambridge, Cambridge, UK.
Expert Rev Vaccines. 2014 Aug;13(8):1027-38. doi: 10.1586/14760584.2014.935767. Epub 2014 Jul 7.
HPV vaccines can prevent multiple cancers in women and men. Difficulties in the cost and completion of the three-dose vaccine series have led to considerations of alternative dose schedules. In clinical trials, three doses given within a 12-month period versus the standard 6-month period yielded comparable results, and immunogenicity appears comparable with two doses in adolescent females compared to the three-dose series in adult females. While the data are generally supportive of moving to a two-dose vaccine schedule among young female adolescents, the adoption of a two-dose vaccine schedule still poses a potential risk to the strength and longevity of the immune response. Public health authorities implementing a two-dose vaccine schedule should devise risk management strategies to minimize the potential impact on cancer prevention.
人乳头瘤病毒（HPV）疫苗可预防女性和男性的多种癌症。三剂疫苗系列在成本和完成接种方面存在困难，因此人们开始考虑采用替代接种方案。在临床试验中，在12个月内接种三剂与标准的6个月接种期产生了相似的结果，并且与成年女性的三剂系列相比，青春期女性接种两剂的免疫原性似乎相当。虽然数据总体上支持在年轻女性青少年中采用两剂疫苗接种方案，但采用两剂疫苗接种方案仍可能对免疫反应的强度和持久性构成潜在风险。实施两剂疫苗接种方案的公共卫生当局应制定风险管理策略，以尽量减少对癌症预防的潜在影响。
