Rhalem A, Bekhti K, Bourdieu C, Luffau G, Péry P
Station de Recherches de Virologie et d'Immunologie, I.N.R.A., Centre de Recherches de Jouy-en-Josas, Domaine de Vilvert.
C R Acad Sci III. 1989;309(1):19-23.
Proteins are released from the surface of sporozoites of Eimeria falciformis during their in vitro incubation in a detergent solution. Some of these proteins reacted with antibodies from infected mice and specifically stimulated the proliferation of mesenteric lymph node cells of these mice. Oral immunization of mice with liposome encapsulated sporozoite surface antigens protected mice against a challenge infection. Two proteins (M.W. 27 and 180 K) induced an antibody synthesis in these vaccinated mice.
在体外于去污剂溶液中孵育期间，蛋白质从镰形艾美耳球虫子孢子表面释放出来。其中一些蛋白质与来自感染小鼠的抗体发生反应，并特异性刺激这些小鼠肠系膜淋巴结细胞的增殖。用脂质体包裹的子孢子表面抗原对小鼠进行口服免疫可保护小鼠免受攻击感染。两种蛋白质（分子量分别为27k和180k）在这些接种疫苗的小鼠中诱导抗体合成。
