Coma Science Group, Cyclotron Research Center and Neurology Department, University of Liege, and University Hospital of Liege, 4000 Liege, Belgium; email:
Annu Rev Neurosci. 2014;37:457-78. doi: 10.1146/annurev-neuro-062012-170339. Epub 2014 Jun 23.
Significant advances have been made in the behavioral assessment and clinical management of disorders of consciousness (DOC). In addition, functional neuroimaging paradigms are now available to help assess consciousness levels in this challenging patient population. The success of these neuroimaging approaches as diagnostic markers is, however, intrinsically linked to understanding the relationships between consciousness and the brain. In this context, a combined theoretical approach to neuroimaging studies is needed. The promise of such theoretically based markers is illustrated by recent findings that used a perturbational approach to assess the levels of consciousness. Further research on the contents of consciousness in DOC is also needed.
在意识障碍（DOC）的行为评估和临床管理方面已经取得了重大进展。此外，现在还可以使用功能神经影像学范式来帮助评估这一具有挑战性的患者群体的意识水平。然而，这些神经影像学方法作为诊断标志物的成功与对意识与大脑之间关系的理解密切相关。在这种情况下，需要采用综合理论方法进行神经影像学研究。最近的一些研究使用摄动方法来评估意识水平，这些研究为基于理论的标志物提供了一些有希望的发现，证明了这种方法的前景。还需要进一步研究 DOC 中的意识内容。
