C反应蛋白的缺失可改善实验性脑型疟疾？
Deletion of C-reactive protein ameliorates experimental cerebral malaria?
作者信息
Szalai Alexander J, Barnum Scott R, Ramos Theresa N
机构信息
Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
出版信息
Trans R Soc Trop Med Hyg. 2014 Sep;108(9):591-3. doi: 10.1093/trstmh/tru098. Epub 2014 Jul 7.
Abstract
BACKGROUND
C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown.
METHODS
Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA).
RESULTS
CRP-deficient mice were most resistant to ECM.
CONCLUSIONS
CRP might contribute to the development of cerebral malaria, rather than protect against it.
摘要
背景
C反应蛋白（CRP）水平与疟原虫血症及疟疾严重程度相关，但这是否反映因果关系尚不清楚。
方法
我们使用CRP转基因小鼠和CRP缺陷小鼠，比较了伯氏疟原虫ANKA株（PbA）诱导的实验性脑型疟疾（ECM）的发病情况和严重程度。
结果
CRP缺陷小鼠对ECM最具抵抗力。
结论
CRP可能促成脑型疟疾的发展，而非起到预防作用。
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