伯氏疟原虫ANKA的克隆株在诱导实验性脑型疟疾的能力上存在差异。
Cloned lines of Plasmodium berghei ANKA differ in their abilities to induce experimental cerebral malaria.
作者信息
Amani V, Boubou M I, Pied S, Marussig M, Walliker D, Mazier D, Rénia L
机构信息
INSERM U313 and Department of Parasitology, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France.
出版信息
Infect Immun. 1998 Sep;66(9):4093-9. doi: 10.1128/IAI.66.9.4093-4099.1998.
Abstract
Infection with Plasmodium berghei ANKA is usually lethal. The parasite causes in some mouse strains a neurovascular syndrome, experimental cerebral malaria (ECM), involving immunopathological reactions. The effects on the development of ECM of the mouse genetic background have been clearly demonstrated, but nothing is known about the effects of the clonal diversity of the parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of ECM induction was dependent on the amount of inoculum. Subtle differences in ECM characteristics (survival time and hypothermia) were also observed. We also confirmed, using the 1.49L cloned line, that the mouse genetic background strongly affects ECM.
摘要
感染伯氏疟原虫ANKA通常是致命的。这种寄生虫在一些小鼠品系中会引发一种神经血管综合征，即实验性脑疟疾（ECM），其中涉及免疫病理反应。小鼠遗传背景对ECM发展的影响已得到明确证实，但关于寄生虫克隆多样性的影响却一无所知。我们发现，源自伯氏疟原虫ANKA多克隆品系的各种克隆株会引发ECM，但ECM诱导的程度取决于接种量。还观察到ECM特征（存活时间和体温过低）存在细微差异。我们还用1.49L克隆株证实，小鼠遗传背景对ECM有强烈影响。
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