免疫功能低下患者：对446例住院患者中发生的最常见感染的回顾。
Immunocompromised patients: Review of the most common infections happened in 446 hospitalized patients.
作者信息
Meidani Mohsen, Naeini Alireza Emami, Rostami Mojtaba, Sherkat Roya, Tayeri Katayoun
机构信息
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2014 Mar;19(Suppl 1):S71-3.
BACKGROUND
Immunodeficiency is a heterogenous group of diseases affecting different components of the immune system. Patterns of infection, etiology and organ involvement are not similar in this risky population. This study was conducted to determine the prevalence of congenital and acquiring immunodeficiencies and also recognizing the most common infections and affected organs.
MATERIALS AND METHODS
In a retrospective, cross-sectional survey, during 2006-2012, we reviewed all hospital records with any kind of immunodeficiency admitted in, all departments of university referral hospital, Isfahan, Iran.
RESULTS
VARIOUS IMMUNODEFICIENCIES, SORTED BY PREVALENCE, WERE AS BELOW: Primary immunodeficiency diseases (PIDs) 122 (27.4%), lymphohematogenous malignancy (LHM) 105 (23.5%), solid cancer 56 (12.6%), human immunodeficiency virus/acquired immunodeficiency syndrome 64 (14.5%), non-cytotoxic immunosuppresion 94 (21%), and splenectomy 5 (1.2%). Common sources of infection were blood, lungs and buccal cavity.
CONCLUSION
The most frequent type of immunodeficiency was PIDs and LHM. Infection continues to be a major problem in all variety of immunodeficiency.
背景
免疫缺陷是一组影响免疫系统不同组成部分的异质性疾病。在这个高危人群中，感染模式、病因和器官受累情况并不相似。本研究旨在确定先天性和获得性免疫缺陷的患病率，并识别最常见的感染及受累器官。
材料与方法
在一项回顾性横断面调查中，我们回顾了2006年至2012年期间伊朗伊斯法罕大学转诊医院所有科室收治的患有任何类型免疫缺陷的患者的医院记录。
结果
按患病率排序的各类免疫缺陷情况如下：原发性免疫缺陷病（PIDs）122例（27.4%），淋巴造血系统恶性肿瘤（LHM）105例（23.5%），实体癌56例（12.6%），人类免疫缺陷病毒/获得性免疫缺陷综合征64例（14.5%），非细胞毒性免疫抑制94例（21%），脾切除术5例（1.2%）。常见的感染源是血液、肺部和口腔。
结论
最常见的免疫缺陷类型是原发性免疫缺陷病和淋巴造血系统恶性肿瘤。感染仍然是各类免疫缺陷中的一个主要问题。
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