Schmid U, Lennert K, Gloor F
Department of Pathology, Kantonsspital, St. Gallen, Switzerland.
Clin Exp Rheumatol. 1989 Mar-Apr;7(2):175-80.
The association of primary salivary gland non-Hodgkin's lymphoma (NHL) and immunosialadenitis (myoepithelial sialadenitis, MESA) is well recognized. Within MESA the whole spectrum of lymphoproliferation starting with a prelymphoma transforming into an early lymphoma and later on into a manifest lymphoma can be observed. These lymphomas represent so-called low grade B-cell lymphomas of mucosa associated lymphoid tissue (MALT), an entity also including lymphoplasmocytoid immunocytoma according to the Kiel classification of NHL. In a few patients a transition into a high grade B-cell lymphoma may occur. The recognition of early stages of lymphomas and their distinction from reactive MESA is only possible by application of immunohistological methods.
原发性涎腺非霍奇金淋巴瘤（NHL）与免疫性涎腺炎（肌上皮涎腺炎，MESA）之间的关联已得到充分认识。在MESA中，可以观察到从淋巴瘤前期转变为早期淋巴瘤，进而发展为明显淋巴瘤的整个淋巴增殖谱。这些淋巴瘤代表所谓的黏膜相关淋巴组织（MALT）低度B细胞淋巴瘤，根据NHL的基尔分类，该实体还包括淋巴浆细胞样免疫细胞瘤。少数患者可能会转变为高度B细胞淋巴瘤。只有通过应用免疫组织学方法，才能识别淋巴瘤的早期阶段并将其与反应性MESA区分开来。
