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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Goodlad R A, Gregory H, Wright N A

Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

Clin Sci (Lond). 1989 Jun;76(6):595-8. doi: 10.1042/cs0760595.

Intestinal epithelial cell proliferation was measured in rats maintained on total parenteral nutrition (TPN), in TPN rats given 300 micrograms of recombinant human epidermal growth factor (urogastrone-epidermal growth factor, URO-EGF) day-1 kg-1, and in further groups given URO-EGF and difluoromethylornithine (DFMO), an inhibitor of the enzyme ornithine decarboxylase (ODC). 2. URO-EGF significantly increased intestinal cell proliferation throughout the gastrointestinal tract. The proliferative response of the colon was particularly pronounced. 3. DFMO reduced the proliferative effect of urogastrone in the stomach and small intestine. DFMO also reduced URO-EGF-stimulated intestinal cell proliferation in the colon, but to a lesser extent. 4. It is concluded that ODC is essential for effecting the proliferative response of the stomach and small intestine to URO-EGF, but this role may be less important in the colon.

测定了接受全胃肠外营养（TPN）的大鼠、每天每千克体重给予300微克重组人表皮生长因子（尿抑胃素 - 表皮生长因子，URO - EGF）的TPN大鼠以及给予URO - EGF和二氟甲基鸟氨酸（DFMO，鸟氨酸脱羧酶（ODC）的抑制剂）的其他组大鼠的肠上皮细胞增殖情况。2. URO - EGF显著增加了整个胃肠道的肠细胞增殖。结肠的增殖反应尤为明显。3. DFMO降低了尿抑胃素在胃和小肠中的增殖作用。DFMO也降低了URO - EGF刺激的结肠肠细胞增殖，但程度较轻。4. 得出的结论是，ODC对于实现胃和小肠对URO - EGF的增殖反应至关重要，但在结肠中该作用可能不太重要。

Goodlad R A, Gregory H, Wright N A

Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

Clin Sci (Lond). 1989 Jun;76(6):595-8. doi: 10.1042/cs0760595.

Intestinal epithelial cell proliferation was measured in rats maintained on total parenteral nutrition (TPN), in TPN rats given 300 micrograms of recombinant human epidermal growth factor (urogastrone-epidermal growth factor, URO-EGF) day-1 kg-1, and in further groups given URO-EGF and difluoromethylornithine (DFMO), an inhibitor of the enzyme ornithine decarboxylase (ODC). 2. URO-EGF significantly increased intestinal cell proliferation throughout the gastrointestinal tract. The proliferative response of the colon was particularly pronounced. 3. DFMO reduced the proliferative effect of urogastrone in the stomach and small intestine. DFMO also reduced URO-EGF-stimulated intestinal cell proliferation in the colon, but to a lesser extent. 4. It is concluded that ODC is essential for effecting the proliferative response of the stomach and small intestine to URO-EGF, but this role may be less important in the colon.

测定了接受全胃肠外营养（TPN）的大鼠、每天每千克体重给予300微克重组人表皮生长因子（尿抑胃素 - 表皮生长因子，URO - EGF）的TPN大鼠以及给予URO - EGF和二氟甲基鸟氨酸（DFMO，鸟氨酸脱羧酶（ODC）的抑制剂）的其他组大鼠的肠上皮细胞增殖情况。2. URO - EGF显著增加了整个胃肠道的肠细胞增殖。结肠的增殖反应尤为明显。3. DFMO降低了尿抑胃素在胃和小肠中的增殖作用。DFMO也降低了URO - EGF刺激的结肠肠细胞增殖，但程度较轻。4. 得出的结论是，ODC对于实现胃和小肠对URO - EGF的增殖反应至关重要，但在结肠中该作用可能不太重要。