Pandya Virat G, Mhaske Santosh B
CSIR-National Chemical Laboratory , Division of Organic Chemistry, Pune 411 008, India.
Org Lett. 2014 Jul 18;16(14):3836-9. doi: 10.1021/ol5018646. Epub 2014 Jul 8.
Sulfones have been attractive targets for synthetic organic chemists owing to their immense applications in medicinal, material, and synthetic chemistry. In this context, an efficient transition-metal-free process has been demonstrated, wherein a broad range of alkyl/aryl/heteroaryl sodium sulfinates react with varyingly substituted aryne precursors (o-silyl aryl triflates) under mild reaction conditions to afford structurally diverse sulfones in good to excellent yields.
由于砜类化合物在药物化学、材料化学和合成化学领域有着广泛的应用,因此一直是有机合成化学家感兴趣的目标。在此背景下,人们已经证明了一种高效的无过渡金属反应过程,即在温和的反应条件下,多种烷基/芳基/杂芳基亚磺酸钠与不同取代的芳炔前体(邻甲硅烷基芳基三氟甲磺酸酯)反应,以良好至优异的产率得到结构多样的砜类化合物。