铜/银介导的由反式-2-羟基肉桂酸和亚磺酸钠构建2-磺酰基苯并[b]呋喃的串联反应。

Copper/silver-mediated cascade reactions for the construction of 2-sulfonylbenzo[b]furans from trans-2-hydroxycinnamic acids and sodium sulfinates.

作者信息

Li Hong-Shuang, Liu Gang

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 2 Nanwei Road, Xicheng District, Beijing 100050, P. R. China.

出版信息

J Org Chem. 2014 Jan 17;79(2):509-16. doi: 10.1021/jo4024478. Epub 2013 Dec 26.

DOI:10.1021/jo4024478

PMID:24354639

Abstract

Efficient construction of 2-sulfonylbenzo[b]furans is achieved from readily available trans-2-hydroxycinnamic acids and sodium sulfinates mediated by the CuCl2·2H2O/AgTFA system under mild conditions. This unprecedented synthetic protocol provides expedient access to a series of products in one step via a protodecarboxylation/C-S bond formation/C-O bond formation cascade.

摘要

在温和条件下，通过CuCl₂·2H₂O/AgTFA体系介导，由易得的反式-2-羟基肉桂酸和亚磺酸钠高效构建2-磺酰基苯并[b]呋喃。这一前所未有的合成方案通过原脱羧/C-S键形成/C-O键形成级联反应一步便捷地获得一系列产物。