College of Life Sciences, Nanjing Normal University, Nanjing 210046, Jiangsu, P. R. China.
Asian Pac J Allergy Immunol. 2014 Jun;32(2):140-4. doi: 10.12932/AP0381.32.2.2013.
To explore the effects of SANPAOCAO (SPC), a compound traditional Chinese folk medicine, on chronic dermatitis/eczema in mice induced by 2, 4-dinitrochlorobenzene (DNCB).
Thirty-three Balb/c mice were randomly divided into a negative control group, a positive control group, a prednisolone treatment group, an SPC ethanol extract treatment group, a Cardiospermum halicacabum ethanol extract treatment group, a Physalis minima ethanol extract treatment group, and a Jussiaea repens ethanol extract treatment group. Mice in the six treatment groups had twenty-five microliters of 0.1% DNCB in acetone/olive oil (3: 1) applied to each side of their right ears and dorsal skin three times a week, over a 5 week period. They were treated with prednisolone or the various kinds of ethanol extract after each challenge. The weight difference between the two ears, pathological changes in the right ears, dermal inflammatory cell numbers, and total serum Ig E levels were used to assess the effects of the drugs.
after the 5 weeks of challenges, the weight differences of the ears in the SPC group and the prednisolone group were significantly less than those in the other groups. There was evidence of significant suppression of the development of dermatitis, as determined by a histological examination and the serum Ig E levels.
SPC has beneficial effects when used in the treatment of chronic dermatitis-eczema in mice.
探讨复方三苞草（SPC）对 2,4-二硝基氯苯（DNCB）诱导的慢性皮炎/湿疹小鼠的作用。
33 只 Balb/c 小鼠随机分为阴性对照组、阳性对照组、泼尼松龙治疗组、SPC 乙醇提取物治疗组、Cardiospermum halicacabum 乙醇提取物治疗组、Physalis minima 乙醇提取物治疗组和 Jussiaea repens 乙醇提取物治疗组。六组治疗组的小鼠在每侧耳和背部皮肤的右侧用 0.1%DNCB 丙酮/橄榄油（3:1）各 25 微升，每周三次，持续 5 周。每次挑战后，它们接受泼尼松龙或各种乙醇提取物的治疗。使用耳重差异、右耳病理变化、真皮炎性细胞数量和总血清 IgE 水平来评估药物的效果。
经过 5 周的挑战，SPC 组和泼尼松龙组的耳重差异明显小于其他组。组织学检查和血清 IgE 水平表明，SPC 对皮炎的发展有明显的抑制作用。
SPC 对治疗小鼠慢性皮炎-湿疹有有益的作用。
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