Böhler S, Wagner K, Bässler K H
Physiologisch-Chemisches Institut, Johannes Gutenberg-Universität Mainz.
Infusionstherapie. 1989 Apr;16(2):82-6.
L-thiazolidine-(4)-carboxylic acid (TAC) has proven to be a good substrate for long-term parenteral nutrition. In this study the metabolism of TAC in the rat is examined at subcellular level. TAC is oxidized by mitochondrial proline oxidase of liver and kidney to L-thiazoline-(4)-carboxylic acid, which then is hydrolyzed to N-formyl-cysteine (FCYS). FCYS is hydrolyzed to cysteine and formic acid by a cytosolic enzyme.
L-噻唑烷-（4）-羧酸（TAC）已被证明是长期肠外营养的良好底物。在本研究中，在亚细胞水平上研究了TAC在大鼠体内的代谢。TAC被肝脏和肾脏的线粒体脯氨酸氧化酶氧化为L-噻唑啉-（4）-羧酸，然后水解为N-甲酰半胱氨酸（FCYS）。FCYS被一种胞质酶水解为半胱氨酸和甲酸。
