Giles Emma K, Lawrence Andrew J, Duncan Jhodie R
Division of Behavioural Neuroscience, Florey Institute of Neuroscience and Mental Health, University of Melbourne, L3, Kenneth Myer Building, Cnr Genetics Lane on Royal Parade, Parkville, VIC, 3010, Australia,
Neurochem Res. 2014 Sep;39(9):1640-7. doi: 10.1007/s11064-014-1379-y. Epub 2014 Jul 9.
This review summarizes recent research on the potential cognitive and behavioural abnormalities induced by exposure to volatile anesthetics and suggests a role of hypoxia-inducible factor (HIF)-1α in mediating these events. Volatile anesthetics are widely utilized in clinical and research settings, yet the long-term safety of exposure to these agents is under debate. Findings from various animal models suggest volatile anesthetics induce widespread apoptosis in the central nervous system (CNS) that correlates with lasting deficits in learning and memory. Longitudinal analysis of clinical data highlight an increased risk of developmental disorders later in life when children are exposed to volatile anesthetics, particularly when exposures occur over multiple sessions. However, the mechanisms underlying these events have yet to be established. Considering the extensive use of volatile anesthetics, it is crucial that these events are better understood. The possible role of HIF-1α in volatile anesthetic-induced CNS abnormalities will be suggested and areas requiring urgent attention will be outlined.
本综述总结了近期关于接触挥发性麻醉剂所诱发的潜在认知和行为异常的研究，并提出缺氧诱导因子（HIF）-1α在介导这些事件中所起的作用。挥发性麻醉剂在临床和研究环境中被广泛使用，然而接触这些药物的长期安全性仍存在争议。各种动物模型的研究结果表明，挥发性麻醉剂可在中枢神经系统（CNS）中诱导广泛的细胞凋亡，这与学习和记忆的持久缺陷相关。临床数据的纵向分析强调，儿童接触挥发性麻醉剂后，尤其是多次接触时，日后发生发育障碍的风险会增加。然而，这些事件背后的机制尚未明确。鉴于挥发性麻醉剂的广泛使用，更好地理解这些事件至关重要。本文将探讨HIF-1α在挥发性麻醉剂诱发的中枢神经系统异常中可能发挥的作用，并概述需要迫切关注的领域。
