大马士革与元生态研究：遥不可及的桥梁。
DAMASCENE and Meta-Ecological Research: A Bridge Too Far.
作者信息
Moyé Lem
机构信息
From the University of Texas Health Science Center School of Public Health, Houston.
出版信息
Circ Res. 2014 Aug 15;115(5):484-7. doi: 10.1161/CIRCRESAHA.114.304767. Epub 2014 Jul 8.
Abstract
Population level studies commonly induce the ecological fallacy i.e., the belief that a relationship identified at the population level implies a cause and effect relationship at the level of the individual. A recent research report (DAMASCENE) that related clinical trial effect sizes in cardiovascular cell therapy trials to reporting discrepancies in the trials themselves has compounded meta-analysis difficulties with ecological fallacy issues. This dangerous combination has produced misleading conclusions and speculation that the research community should set aside.
摘要
群体水平研究通常会引发生态谬误，即认为在群体水平上确定的关系意味着个体水平上的因果关系。最近一份研究报告（DAMASCENE）将心血管细胞治疗试验中的临床试验效应大小与试验本身的报告差异联系起来，这使得荟萃分析因生态谬误问题而更加困难。这种危险的组合产生了误导性结论和猜测，科学界应该摒弃这些结论和猜测。
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