Miranda Cleine Aglacy Nunes, Lima Erika Galvão, de Lima Diego Breno Soares, Cobucci Ricardo Ney Oliveira, Cornetta Maria da Conceição de Mesquita, Fernandes Thales Allyrio Araújo de Medeiros, de Azevedo Paulo Roberto Medeiros, de Azevedo Jenner Chrystian Veríssimo, de Araújo Josélio Maria Galvão, Fernandes José Veríssimo
Post-Graduate Program in Biological Sciences, Federal University of Rio Grande do Norte, Avenida Salgado Filho, S/N, Campus Universitario, Lagoa Nova, 59072-970 Natal, RN, Brazil.
Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Avenida General Gustavo de Farias, S/N, Petropolis, 59012-570 Natal, RN, Brazil.
ISRN Obstet Gynecol. 2014 Mar 11;2014:323657. doi: 10.1155/2014/323657. eCollection 2014.
Objective. To evaluate the prevalence of HSV-1 and HSV-2 in pregnant and nonpregnant women, testing the correlation between DNA of the viruses with colposcopic and/or cytological changes, and evaluate association with sociodemographic characteristics and sexual activity. Methods. Included in this study were 106 pregnant and 130 nonpregnant women treated at primary health care units of Natal, Brazil, in the period 2010-2011. The patients were examined by colposcopy, and two cervical specimens were collected: one for cytology examination and another for analysis by PCR for detection of HSV-1 and HSV-2. Results. HSV-1 alone was detected in 16.0% of pregnant and 30.0% of nonpregnant women. For HSV-2, these rates were 12.3% and 15.5%, respectively. HSV-2 had a higher correlation with cytology and/or colposcopy changes than HSV-1 did. Genital HSV-1 infection was not associated with any of the variables tested, whereas HSV-2 infection was associated with ethnicity, marital status, and number of sexual partners. Conclusions. The prevalence of HSV-1 was higher than that observed for HSV-2 in both pregnant and nonpregnant women. The genital infection by HSV-2 was higher in women with changed colposcopy and/or cytology, and it was associated with ethnicity, marital status, and number of sexual partners.
目的。评估孕妇和非孕妇中单纯疱疹病毒1型（HSV-1）和单纯疱疹病毒2型（HSV-2）的流行情况，检测病毒DNA与阴道镜和/或细胞学变化之间的相关性，并评估其与社会人口学特征和性活动的关联。方法。本研究纳入了2010年至2011年期间在巴西纳塔尔初级卫生保健单位接受治疗的106名孕妇和130名非孕妇。对患者进行阴道镜检查，并采集两份宫颈标本：一份用于细胞学检查，另一份用于通过聚合酶链反应（PCR）分析检测HSV-1和HSV-2。结果。仅检测到HSV-1的孕妇比例为16.0%，非孕妇为30.0%。对于HSV-2，这些比例分别为12.3%和15.5%。与HSV-1相比，HSV-2与细胞学和/或阴道镜变化的相关性更高。生殖器HSV-1感染与所检测的任何变量均无关联，而HSV-2感染与种族、婚姻状况和性伴侣数量有关。结论。孕妇和非孕妇中HSV-1的流行率均高于HSV-2。阴道镜和/或细胞学改变的女性中HSV-2生殖器感染率更高，且与种族、婚姻状况和性伴侣数量有关。
