Brestel E P, Koes M T
Department of Medicine, University School of Medicine, Morgantown, WV 26506.
Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):21-4. doi: 10.1016/0952-3278(89)90157-9.
Previous studies have shown heparin to have antiinflammatory properties. We have attempted to determine if the mechanism involves the inhibition of lipid oxidation by utilizing a model system where linoleic acid is oxidized in the presence of oxygen and methemoglobin. Heparin inhibits this "quasi-lipoxygenase" activity prolonging the lag phase and slowing the rate of lipid peroxidation. An oxidant scavenging mechanism is also inferred from the fact that heparin is capable of inhibiting luminol-dependent chemiluminescence resulting from the reduction of 15-HPETE by methemoglobin. It is concluded that heparin, in at least this model system, is capable of inhibiting lipoxygenation by an oxidant scavenging mechanism.
先前的研究表明肝素具有抗炎特性。我们试图通过利用一个模型系统来确定其机制是否涉及对脂质氧化的抑制，在该模型系统中，亚油酸在氧气和高铁血红蛋白存在的情况下被氧化。肝素抑制这种“准脂氧合酶”活性，延长延迟期并减缓脂质过氧化速率。从肝素能够抑制高铁血红蛋白还原15 - HPETE所产生的鲁米诺依赖性化学发光这一事实中，也可推断出一种抗氧化剂清除机制。得出的结论是，至少在这个模型系统中，肝素能够通过抗氧化剂清除机制抑制脂氧合作用。
