Marchesi C, Campanini T, Govi A, Tampieri E, Gnudi A, Chiodera P, Coiro V
Postgraduate School of Psychiatry, University Hospital, Parma, Italy.
Psychiatry Res. 1989 Apr;28(1):89-96. doi: 10.1016/0165-1781(89)90200-x.
The thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) responses to thyrotropin releasing hormone (TRH), the Wechsler Adult Intelligence Scale (WAIS) for cognitive impairment, and computed tomographic scans were evaluated in 15 nondepressed alcoholic men after 4 weeks of abstinence and in 10 normal controls. Both cognitive impairment and cerebral atrophy were found in 13 of the alcoholics. Eight alcoholics (seven with cerebral atrophy) had blunted TSH and PRL responses to TRH and a TRH-induced paradoxical increase of GH. This study demonstrates that besides affecting the TSH response to TRH, alcoholism often induces alterations of the PRL and GH secretory patterns in response to TRH. The severe brain damage caused by long-term alcoholism might be involved in the pathogenesis of these neuroendocrine alterations.
对15名戒酒4周的非抑郁男性酗酒者和10名正常对照者，评估了促甲状腺激素（TSH）、催乳素（PRL）和生长激素（GH）对促甲状腺激素释放激素（TRH）的反应、用于评估认知障碍的韦氏成人智力量表（WAIS）以及计算机断层扫描。13名酗酒者存在认知障碍和脑萎缩。8名酗酒者（7名伴有脑萎缩）对TRH的TSH和PRL反应迟钝，且TRH诱导GH出现反常升高。本研究表明，酗酒除了影响TSH对TRH的反应外，还常导致PRL和GH对TRH分泌模式的改变。长期酗酒所致的严重脑损伤可能参与了这些神经内分泌改变的发病机制。
