Baulac M, Smadja D, Cabrol A, Cabrol C, LaPlane D
Clinique des Maladies du Système Nerveux, La Salpétrière, Paris.
Rev Neurol (Paris). 1989;145(5):393-7.
6 p. 100 of a population of 129 heart transplant recipients presented isolated convulsions under cyclosporin (Ci) immunosuppressive treatment. These seizures were unexplained by acute causes, infectious or cerebro-vascular. Seizures started generally a few days after Ci therapy onset, and led often to severe convulsive states, with sometimes a status epilepticus. For most of them, Ci serum levels were within, or just above, the recommended therapeutic range. Ischemic brain damage that occurred prior to surgery and Ci therapy, could be a contributing factor to Ci-induced seizures in this population of heart transplant recipients.
在129名心脏移植受者中，有6人（占比100分之6）在接受环孢素（Ci）免疫抑制治疗时出现了孤立性惊厥。这些癫痫发作无法用急性病因（感染性或脑血管性）来解释。癫痫发作通常在Ci治疗开始几天后开始，并且常常导致严重的惊厥状态，有时还会出现癫痫持续状态。对于大多数患者而言，Ci血清水平在推荐的治疗范围内或略高于该范围。手术和Ci治疗之前发生的缺血性脑损伤可能是导致这群心脏移植受者出现Ci诱导性癫痫发作的一个因素。
