Bruun N E, Skøtt P, Lønborg-Jensen H, Giese J
Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark.
Scand J Clin Lab Invest. 1989 May;49(3):259-63.
To evaluate the validity of the lithium clearance method as a marker of overall proximal tubular fluid delivery in moderately sodium-depleted humans, the effects of a single dose of 10 mg amiloride on lithium clearance and glomerular filtration-rate were studied in normal volunteers maintained on a sodium diet of 50 mmol/day. Amiloride caused no changes of the glomerular filtration-rate or of lithium clearance. The effects of amiloride on tubular sodium, potassium and water handling were in accordance with a distal tubular action of amiloride. The results suggest that significant distal lithium reabsorption does not occur in measurable amounts during moderate sodium depletion in humans. The lithium clearance method may, therefore, be used to assess proximal fluid delivery in man when dietary sodium intake is as low as in the present study.
为评估锂清除率方法作为中度缺钠人群近端肾小管总体液体输送标志物的有效性，在每日钠摄入量为50 mmol的正常志愿者中，研究了单剂量10 mg氨氯吡咪对锂清除率和肾小球滤过率的影响。氨氯吡咪未引起肾小球滤过率或锂清除率的变化。氨氯吡咪对肾小管钠、钾和水处理的影响与氨氯吡咪的远端肾小管作用一致。结果表明，在人类中度缺钠期间，未发生可测量量的显著远端锂重吸收。因此，当饮食钠摄入量如本研究中那样低时，锂清除率方法可用于评估人体近端液体输送情况。
