Katsuda Shin-ichiro, Takazawa Kenji, Miyake Masao, Kobayashi Daisuke, Kusanagi Masahiko, Hazama Akihiro
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Department of Cardiology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
Hypertens Res. 2014 Oct;37(10):892-900. doi: 10.1038/hr.2014.96. Epub 2014 Jul 10.
We investigated local pulse wave velocity (LPWV) in different aortic segments with respect to the rheological properties of the aorta with age-related progression of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Normal and KHC rabbits aged 10-12, 22-24 and 34-36 months were anesthetized with pentobarbital sodium (30 mg kg(-1), intravenous). Pulse waves at the ascending aorta were recorded simultaneously with those at the proximal, middle and distal thoracic and abdominal aortas by moving a catheter with three micromanometers (40-mm intervals) at 80-mm intervals from the origin of the descending thoracic aorta. The aortic diameter was measured using an intravascular imaging system at the same aortic position at which the pulse waves were measured. LPWV was the greatest in the aortic arch, decreased gradually in the thoracic aorta and increased again in the abdominal aorta in KHC rabbits, whereas it was the lowest in the aortic arch, increased slightly in the thoracic aorta and increased gradually in the abdominal aorta in normal rabbits. LPWV increased significantly with age in most aortic segments. The change pattern of LPWV resembled that of the percent fractional lesioned area where LPWV was determined. The significant increase in LPWV with age was mainly due to the increase in the elastic modulus of the aortic wall with atherosclerotic progression as well as the increase in wall thickness. LPWV accurately detected the presence of atherosclerotic lesions and alteration in the rheological properties of the aortic regions through which pulse waves travelled.
我们研究了黑泽和草柳高胆固醇血症（KHC）兔主动脉粥样硬化随年龄进展过程中不同主动脉节段的局部脉搏波速度（LPWV）与主动脉流变学特性的关系。将10 - 12个月、22 - 24个月和34 - 36个月的正常兔和KHC兔用戊巴比妥钠（30 mg kg⁻¹，静脉注射）麻醉。通过将带有三个微测压计（间隔40 mm）的导管从胸降主动脉起始处以80 mm间隔移动，同时记录升主动脉与胸主动脉近端、中段和远端以及腹主动脉的脉搏波。使用血管内成像系统在测量脉搏波的相同主动脉位置测量主动脉直径。在KHC兔中，LPWV在主动脉弓处最大，在胸主动脉中逐渐降低，在腹主动脉中再次升高；而在正常兔中，LPWV在主动脉弓处最低，在胸主动脉中略有升高，在腹主动脉中逐渐升高。大多数主动脉节段的LPWV随年龄显著增加。LPWV的变化模式与确定LPWV处的病变面积百分比的变化模式相似。LPWV随年龄的显著增加主要是由于随着动脉粥样硬化进展主动脉壁弹性模量增加以及壁厚增加。LPWV准确地检测到了动脉粥样硬化病变的存在以及脉搏波传播所经过的主动脉区域流变学特性的改变。
