Tanaka Katsuya, Akita Sadanori, Yoshimoto Hiroshi, Houbara Seiji, Hirano Akiyoshi
Nagasaki University, Nagasaki, Japan.
Nagasaki University, Nagasaki, Japan
Int J Low Extrem Wounds. 2014 Sep;13(3):220-5. doi: 10.1177/1534734614541544. Epub 2014 Jul 8.
Donor-site wound healing was tested with a nonadherent petrolatum- and hydrocolloid-impregnated polyester, a lipid-colloid dressing, and a nonadherent polyester dressing, supplemented with petrolatum manually by a physician onsite. Ten patients, 1 woman and 9 men (22 to 79 years old; average 58.4 ± 17.54 years), were enrolled in this prospective comparison study. The split-thickness skin graft was 14.5 ± 7.49 cm long × 8.2 ± 4.07 cm wide (5.5-27 cm long and 4.0-14.0 wide) and 14/1000 inches (0.356 mm) deep. The degree of reepithelialization in lipid-colloid dressing was significantly better than that in polyester mesh dressing, with 1.7 ± 1.00 and 2.8 ± 0.83 for the lipid-colloid dressing and polyester mesh dressing, respectively (P < .05), and degree of pain was significantly lower in lipid-colloid dressing than that in polyester dressing, 1.7 ± 1.11 and 2.9 ± 1.12 for the lipid-colloid dressing and polyester mesh dressing, respectively (P < .01). In moisture meter analyses, the values of effective contact coefficient and corneal thickness in lipid-colloid at wound healing was significantly smaller than those in polyester mesh (effective contact coefficient: 11.7 ± 1.87% and 15.6 ± 3.09% for lipid-colloid and polyester mesh, respectively, P < .05; corneal thickness: 31.1 ± 6.65 µm and 40.7 ± 8.69 µm for lipid-colloid and polyester mesh, respectively, P < .05). No significant difference was observed at 1 month after healing. The nonadherent lipid-colloid polyester dressing has superior wound healing and pain relief and demonstrates better corneal barrier function delineated by effective contact coefficient and corneal thickness at healing in split-thickness donors.
采用一种非粘性的凡士林和水胶体浸渍聚酯、一种脂质胶体敷料以及一种非粘性聚酯敷料对供皮区伤口愈合情况进行测试，医生在现场手动补充凡士林。10名患者（1名女性和9名男性，年龄22至79岁，平均58.4±17.54岁）参与了这项前瞻性对比研究。断层皮片长14.5±7.49厘米×宽8.2±4.07厘米（长5.5 - 27厘米，宽4.0 - 14.0厘米），深14/1000英寸（0.356毫米）。脂质胶体敷料的再上皮化程度明显优于聚酯网眼敷料，脂质胶体敷料和聚酯网眼敷料的再上皮化程度分别为1.7±1.00和2.8±0.83（P<.05），脂质胶体敷料的疼痛程度明显低于聚酯敷料，脂质胶体敷料和聚酯网眼敷料的疼痛程度分别为1.7±1.11和2.9±1.12（P<.01）。在水分测定分析中，伤口愈合时脂质胶体的有效接触系数值和角膜厚度明显小于聚酯网眼（有效接触系数：脂质胶体和聚酯网眼分别为11.7±1.87%和15.6±3.09%，P<.05；角膜厚度：脂质胶体和聚酯网眼分别为31.1±6.65微米和40.7±8.69微米，P<.05）。愈合后1个月未观察到显著差异。非粘性脂质胶体聚酯敷料在供皮区伤口愈合和缓解疼痛方面具有优势，并且在断层供皮区愈合时通过有效接触系数和角膜厚度所显示的角膜屏障功能更好。
