一例由甲氧苄啶-磺胺甲恶唑引起的中毒性表皮坏死松解症。
A case of toxic epidermal necrolysis caused by trimethoprim-sulfamethoxazole.
作者信息
Rijal Jharendra P, Pompa Tiffany, Giri Smith, Bhatt Vijaya Raj
机构信息
Miriam Hospital, Providence, Rhode Island, USA.
Staten Island University Hospital, Staten Island, New York, USA.
出版信息
BMJ Case Rep. 2014 Jul 9;2014:bcr2013203163. doi: 10.1136/bcr-2013-203163.
Abstract
Toxic epidermal necrolysis (TEN) is a rare but serious dermatological emergency characterised by diffuse exfoliation of the skin and mucous membranes due to immune mediated destruction of the epidermis which can lead to sepsis and respiratory distress. Trimethoprim-sulfamethoxazole is a widely used antibiotic which can rarely lead to TEN. Early diagnosis and aggressive medical care is essential for the reduction of high morbidity and mortality associated with this disease. We present a case of successfully recovered TEN due to trimethoprim-sulfamethoxazole in a 62-year-old woman.
摘要
中毒性表皮坏死松解症（TEN）是一种罕见但严重的皮肤科急症，其特征是由于表皮的免疫介导性破坏导致皮肤和黏膜弥漫性剥脱，可导致败血症和呼吸窘迫。甲氧苄啶-磺胺甲恶唑是一种广泛使用的抗生素，很少会导致TEN。早期诊断和积极的医疗护理对于降低与该疾病相关的高发病率和死亡率至关重要。我们报告一例62岁女性因甲氧苄啶-磺胺甲恶唑导致的TEN成功康复的病例。
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