The University of Sydney, Sydney, New South Wales, Australia.
J Am Acad Dermatol. 2012 Jun;66(6):995-1003. doi: 10.1016/j.jaad.2011.09.029. Epub 2011 Dec 9.
Toxic epidermal necrolysis (TEN) is a severe cutaneous drug reaction with a mortality rate of approximately 30%. The hallmark of TEN is widespread epidermal sloughing due to keratinocyte apoptosis. Multiple genetic associations between TEN and specific ethnic populations have been determined. The pathophysiology of TEN has yet to be fully elucidated; however, current pathogenic models implicate Fas ligand, granulysin, and reactive oxygen species. The value of current therapies, such as intravenous immunoglobulin and corticosteroids, remains under evaluation.
中毒性表皮坏死松解症（TEN）是一种严重的皮肤药物反应，死亡率约为 30%。TEN 的特征是由于角质形成细胞凋亡导致广泛的表皮脱落。已经确定 TEN 与特定种族群体之间存在多种遗传关联。TEN 的病理生理学尚未完全阐明；然而，目前的发病机制模型涉及 Fas 配体、颗粒溶素和活性氧。目前疗法的价值，如静脉注射免疫球蛋白和皮质类固醇，仍在评估中。
