1] Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven B-3000, Belgium [2] Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B-3000, Belgium.
Nature. 2014 Jul 10;511(7508):167-76. doi: 10.1038/nature13312.
Cancer cells have been at the centre of cell metabolism research, but the metabolism of stromal and immune cells has received less attention. Nonetheless, these cells influence the progression of malignant, inflammatory and metabolic disorders. Here we discuss the metabolic adaptations of stromal and immune cells in health and disease, and highlight how metabolism determines their differentiation and function.
癌细胞一直是细胞代谢研究的核心，但基质细胞和免疫细胞的代谢却较少受到关注。尽管如此，这些细胞还是会影响恶性肿瘤、炎症和代谢紊乱的进展。本文讨论了基质细胞和免疫细胞在健康和疾病中的代谢适应性，并强调了代谢如何决定它们的分化和功能。
