Tomonaga K, Kurono Y, Chaen T, Mogi G
Department of Otolaryngology, Medical College of Oita, Japan.
Am J Otolaryngol. 1989 May-Jun;10(3):204-7. doi: 10.1016/0196-0709(89)90064-1.
In order to clarify the role of the microflora of the nasopharynx and adenoids as causative factors of otitis media with effusion (OME), bacteriologic species in middle ear effusions (MEEs), nasopharyngeal smears, and adenoid tissues of children with OME were cultured. The change in the microflora of the nasopharynx after adenoidectomy, and the degree of bacterial agreement between the microflora of the nasopharynx and adenoid tissue were investigated. Nasopharyngeal bacterial flora were investigated in 259 children with OME from November 1984 to November 1987. The patients were divided into two groups: group A (43 patients) underwent adenoidectomy, and group B (216 patients) had no adenoidectomy. Hemophilus influenzae, Streptococcus pneumoniae, Branhamella catarrhalis, and Staphylococcus aureus were cultured in 66.7% of nasopharyngeal smears from group B, and in 46.5% from group A. Adenoid specimens for bacteriologic investigation were obtained from 38 adenoidectomy patients at surgery. Of these, H influenzae were cultured from adenoid specimens taken from 16 of the 26 patients with OME (group C), while only three of the 12 adenoidectomy patients without OME (group D) were found to have H influenzae in their adenoid specimens. The findings of this study suggest that adenoid vegetation plays an important role in the etiology of OME.
为了阐明鼻咽部和腺样体微生物群作为分泌性中耳炎（OME）致病因素的作用，对OME患儿的中耳积液（MEE）、鼻咽涂片和腺样体组织中的细菌种类进行了培养。研究了腺样体切除术后鼻咽部微生物群的变化，以及鼻咽部和腺样体组织微生物群之间的细菌一致性程度。1984年11月至1987年11月，对259例OME患儿的鼻咽部细菌菌群进行了研究。患者分为两组：A组（43例）接受了腺样体切除术，B组（216例）未接受腺样体切除术。B组66.7%的鼻咽涂片培养出流感嗜血杆菌、肺炎链球菌、卡他布兰汉菌和金黄色葡萄球菌，A组为46.5%。从38例接受腺样体切除术的患者手术中获取腺样体标本进行细菌学检查。其中，26例OME患者（C组）中有16例的腺样体标本培养出流感嗜血杆菌，而12例无OME的腺样体切除患者（D组）中只有3例的腺样体标本中发现有流感嗜血杆菌。本研究结果表明腺样体增生在OME的病因学中起重要作用。
