Tarnopolsky Mark A
From the Division of Neuromuscular and Neurometabolic Diseases, McMaster University, Hamilton, Ontario, Canada
J Child Neurol. 2014 Sep;29(9):1225-34. doi: 10.1177/0883073814538512. Epub 2014 Jul 9.
Patients with mitochondrial cytopathies often experience exercise intolerance and may have fixed muscle weakness, leading to impaired functional capacity and lower quality of life. Endurance exercise training increases Vo 2 max, respiratory chain enzyme activity, and improves quality of life. Resistance exercise training increases muscle strength and may lower mutational burden in patients with mitochondrial DNA deletions. Both modes of exercise appear to be well tolerated. Patients with mitochondrial cytopathy should consider alternating both types of exercise to derive the benefits from each (endurance = greater aerobic fitness; resistance = greater strength). Patients should start an exercise program at a low intensity and duration, gradually increasing duration and intensity. They should "listen to their body" and not exercise on days they have fever, superimposed illness, muscle pain, or cramps, and/or if they have fasted for more than 12 hours. Children often respond best to play-based exercise and tend to enjoy intermittent activity.
线粒体细胞病患者常出现运动不耐受，可能存在固定性肌肉无力，导致功能能力受损和生活质量下降。耐力运动训练可提高最大摄氧量、呼吸链酶活性，并改善生活质量。抗阻运动训练可增强肌肉力量，并可能降低线粒体DNA缺失患者的突变负担。两种运动方式似乎耐受性都良好。线粒体细胞病患者应考虑交替进行这两种运动，以从每种运动中获益（耐力运动 = 更好的有氧适能；抗阻运动 = 更强的力量）。患者应从低强度、短时长的运动计划开始，逐渐增加时长和强度。他们应“倾听身体的声音”，在发烧、并发疾病、肌肉疼痛或抽筋的日子，以及/或者禁食超过12小时时不要运动。儿童通常对基于游戏的运动反应最佳，往往喜欢间歇性活动。
