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自闭症谱系障碍社交故事在学校的试验(ASSSIST):一项可行性随机对照试验的研究方案,分析社交故事在主流学校中的临床效果和成本效益。

Autism Spectrum Social Stories In Schools Trial (ASSSIST): study protocol for a feasibility randomised controlled trial analysing clinical and cost-effectiveness of Social Stories in mainstream schools.

作者信息

Wright Barry, Marshall David, Collingridge Moore Danielle, Ainsworth Hannah, Hackney Lisa, Adamson Joy, Ali Shehzad, Allgar Victoria, Cook Liz, Dyson Lisa, Littlewood Elizabeth, Hargate Rebecca, McLaren Anne, McMillan Dean, Trépel Dominic, Whitehead Jo, Williams Chris

机构信息

Research Team, Lime Trees CAMHS, York, UK.

Department of Health Sciences, University of York, York, UK.

出版信息

BMJ Open. 2014 Jul 9;4(7):e005952. doi: 10.1136/bmjopen-2014-005952.

Abstract

INTRODUCTION

Current evidence suggests that Social Stories can be effective in tackling problem behaviours exhibited by children with autism spectrum disorder. Exploring the meaning of behaviour from a child's perspective allows stories to provide social information that is tailored to their needs. Case reports in children with autism have suggested that these stories can lead to a number of benefits including improvements in social interactions and choice making in educational settings.

METHODS AND ANALYSIS

The feasibility of clinical and cost-effectiveness of a Social Stories toolkit will be assessed using a randomised control framework. Participants (n=50) will be randomised to either the Social Stories intervention or a comparator group where they will be read standard stories for an equivalent amount of time. Statistics will be calculated for recruitment rates, follow-up rates and attrition. Economic analysis will determine appropriate measures of generic health and resource use categories for cost-effectiveness analysis. Qualitative analysis will ascertain information on perceptions about the feasibility and acceptability of the intervention.

ETHICS AND DISSEMINATION

National Health Service Ethics Approval (NHS; ref 11/YH/0340) for the trial protocol has been obtained along with NHS Research and Development permission from Leeds and York Partnership NHS Foundation Trust. All adverse events will be closely monitored, documented and reported to the study Data Monitoring Ethics Committee. At least one article in a peer reviewed journal will be published and research findings presented at relevant conferences.

TRIAL REGISTRATION NUMBER

ISRCTN96286707.

摘要

引言

目前的证据表明,社交故事在应对自闭症谱系障碍儿童表现出的问题行为方面可能有效。从儿童的角度探索行为的意义,能使故事提供符合其需求的社交信息。自闭症儿童的病例报告表明,这些故事能带来诸多益处,包括改善社交互动以及在教育环境中的决策能力。

方法与分析

将使用随机对照框架评估社交故事工具包的临床可行性和成本效益。参与者(n = 50)将被随机分为社交故事干预组或对照组,对照组将在相同时间内阅读标准故事。将计算招募率、随访率和损耗率。经济分析将确定用于成本效益分析的一般健康和资源使用类别的适当衡量指标。定性分析将确定有关干预措施的可行性和可接受性的看法信息。

伦理与传播

已获得英国国家医疗服务体系伦理批准(NHS;参考编号11/YH/0340)用于试验方案,同时获得了利兹和约克伙伴关系国民保健服务基金会信托基金的NHS研发许可。将密切监测、记录所有不良事件并报告给研究数据监测伦理委员会。将在同行评审期刊上发表至少一篇文章,并在相关会议上展示研究结果。

试验注册号

ISRCTN96286707。

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