Saxena S, Korula J, Shulman I A
Interpretive Clinical Pathology Unit, Los Angeles County-University of Southern California (LAC-USC) Medical Center.
Arch Pathol Lab Med. 1989 Jul;113(7):767-71.
To reduce the incidence of post-transfusion non-A, non-B hepatitis, the American Association of Blood Banks has required that serum alanine aminotransferase activity be used to screen blood donors. Consequently, approximately 2% to 3% of all blood donations will be discarded owing to an elevated alanine aminotransferase level. In addition, approximately 0.7% of blood donors will be notified of an abnormal alanine aminotransferase result. While some of these donors may have viral hepatitis, factors such as the donor's age, gender, body weight, ethnic background, alcohol intake, diet, and exercise must also be considered when interpreting an elevated alanine aminotransferase level. Donors with significant or persistently elevated alanine aminotransferase levels should have their conditions evaluated so that treatable diseases can be recognized and/or treated.
为降低输血后非甲非乙型肝炎的发病率，美国血库协会要求使用血清丙氨酸氨基转移酶活性来筛查献血者。因此，所有献血中约有2%至3%将因丙氨酸氨基转移酶水平升高而被丢弃。此外，约0.7%的献血者将被告知丙氨酸氨基转移酶结果异常。虽然这些献血者中有些可能患有病毒性肝炎，但在解读丙氨酸氨基转移酶水平升高时，还必须考虑献血者的年龄、性别、体重、种族背景、酒精摄入量、饮食和运动等因素。丙氨酸氨基转移酶水平显著或持续升高的献血者应评估其病情，以便识别和/或治疗可治疗的疾病。
