Tashian R E
Bioessays. 1989 Jun;10(6):186-92. doi: 10.1002/bies.950100603.
Now, some 55 years after its discovery in bovine red cells, carbonic anhydrase (CA), in all its varied forms, continues to challenge and intrigue physiologists, biochemists and molecular geneticists. This is so because of an increasing awareness of the many apparently diverse functions of the different CA isozymes encoded by this large multigene family, the continuing discovery of new CA, or CA-related, genes, and the extensive variation in their hormonal control, cellular expression and subcellular localization.
如今，在牛红细胞中发现碳酸酐酶（CA）约55年后，其各种不同形式仍在不断挑战并吸引着生理学家、生物化学家及分子遗传学家。之所以如此，是因为人们越来越意识到这个庞大的多基因家族所编码的不同CA同工酶具有许多明显多样的功能，不断有新的CA或与CA相关的基因被发现，以及它们在激素调控、细胞表达和亚细胞定位方面存在广泛差异。
