Kim Hyeong Jae, Hong Jeong Hee
Department of Physiology, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Republic of Korea.
Pharmaceutics. 2024 Jan 5;16(1):78. doi: 10.3390/pharmaceutics16010078.
Bicarbonate transporters are responsible for the appropriate flux of bicarbonate across the plasma membrane to perform various fundamental cellular functions. The functions of bicarbonate transporters, including pH regulation, cell migration, and inflammation, are highlighted in various cellular systems, encompassing their participation in both physiological and pathological processes. In this review, we focused on recently identified modulatory signaling components that regulate the expression and activity of bicarbonate transporters. Moreover, we addressed recent advances in our understanding of cooperative systems of bicarbonate transporters and channelopathies. This current review aims to provide a new, in-depth understanding of numerous human diseases associated with the dysfunction of bicarbonate transporters.
碳酸氢盐转运体负责碳酸氢盐在质膜上的适当通量，以执行各种基本的细胞功能。碳酸氢盐转运体的功能，包括pH调节、细胞迁移和炎症，在各种细胞系统中都有突出表现，涵盖了它们在生理和病理过程中的参与。在本综述中，我们重点关注了最近发现的调节碳酸氢盐转运体表达和活性的调节信号成分。此外，我们还讨论了在理解碳酸氢盐转运体协同系统和通道病方面的最新进展。本综述旨在为与碳酸氢盐转运体功能障碍相关的众多人类疾病提供新的、深入的理解。
