Hashmi Atif Ali, Faridi Naveen, Malik Babar, Edhi Muhammad Muzzammil, Khurshid Amna, Khan Mehmood
Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.
Department of medical oncology, Sindh institute of urology and transplantation, Karachi, Pakistan.
Int Arch Med. 2014 Jun 27;7:33. doi: 10.1186/1755-7682-7-33. eCollection 2014.
Glial tumors are most common brain tumors in our population. While the exact etiology and pathogenesis is unknown, the evaluation of current trends in the frequency and morphology of glial tumors is imperative to constitute better diagnostic and treatment protocols. Data pertaining to frequency and spectrum of glial tumors is scarcely available in our population. The aim of this study was to determine the morphologic spectrum of glial tumors prevalent in our population.
126 cases of glial tumors were retrospectively analyzed over a period of 5 years. Patients from all age groups and both genders were included in this study. Glial tumors were classified and graded according to WHO classification.
Glial tumors were more common in males with a sex ratio of 2:1 and mean age of 38.26 years. Astrocytomas were most common glial tumors (51.6%) followed by oligodendrogliomas (23%). Glioblastoma was the most frequent astrocytic tumor and was incomparably frequent in older age group.
In our study, Oligodendrogliomas and mixed oligoastrocytomas represent major pattern of disease in comparison with available regional data. Knowledge of these changing trends and patterns of glial tumor morphology and frequency can help in improvements and applications of newly emerging diagnostic and treatment modalities.
胶质肿瘤是我国人群中最常见的脑肿瘤。虽然确切的病因和发病机制尚不清楚，但评估胶质肿瘤的频率和形态学的当前趋势对于制定更好的诊断和治疗方案至关重要。在我国人群中，关于胶质肿瘤的频率和谱系的数据很少。本研究的目的是确定我国人群中普遍存在的胶质肿瘤的形态学谱系。
回顾性分析5年间126例胶质肿瘤病例。本研究纳入了所有年龄组和性别的患者。胶质肿瘤根据世界卫生组织分类进行分类和分级。
胶质肿瘤在男性中更为常见，性别比为2:1，平均年龄为38.26岁。星形细胞瘤是最常见的胶质肿瘤（51.6%），其次是少突胶质细胞瘤（23%）。胶质母细胞瘤是最常见的星形细胞肿瘤，在老年组中极为常见。
在我们的研究中，与现有的区域数据相比，少突胶质细胞瘤和混合性少突星形细胞瘤是主要的疾病模式。了解这些胶质肿瘤形态和频率的变化趋势和模式有助于新兴诊断和治疗方式的改进和应用。
