Lu Yongping, Wei Jia, Tang Yueyue, Yuan Yuan, Huang Yanling, Zhang Yong, Li Yunyan
Department of Ultrasound, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, P.R. China.
The Liver Disease Center, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, P.R. China.
Exp Ther Med. 2014 Aug;8(2):355-362. doi: 10.3892/etm.2014.1749. Epub 2014 May 29.
The aim of the present study was to detect the elastic modulus (stiffness) of the livers of rabbits with non-alcoholic and alcoholic fatty liver disease using real-time shear wave elastography (SWE), and to investigate the fibrosis development process in the formation of fatty liver. The stiffness of the fatty livers in rabbit models prepared via feeding with alcohol or a high-fat diet were measured using a real-time SWE ultrasound system and a 4-15-MHz linear array probe, and the liver stiffness was compared with the pathological staging of the disease. The stiffness of the liver was positively correlated with the degree of pathological change in fatty liver disease (P<0.01). The stiffness of the liver in the alcoholic fatty liver group was higher compared with that in the non-alcoholic fatty liver and control groups, and the stiffness in the non-alcoholic fatty liver group was higher than that in the control group (P<0.01). Real-time SWE objectively identified the trend in the changing stiffness of the liver and noninvasively detected the development of fibrosis in the progression of non-alcoholic and alcoholic fatty liver disease.
本研究的目的是使用实时剪切波弹性成像（SWE）检测非酒精性和酒精性脂肪性肝病家兔肝脏的弹性模量（硬度），并研究脂肪肝形成过程中的纤维化发展过程。使用实时SWE超声系统和4-15MHz线性阵列探头测量通过喂食酒精或高脂饮食制备的家兔模型中脂肪肝的硬度，并将肝脏硬度与疾病的病理分期进行比较。肝脏硬度与脂肪性肝病的病理变化程度呈正相关（P<0.01）。酒精性脂肪肝组肝脏的硬度高于非酒精性脂肪肝组和对照组，非酒精性脂肪肝组的硬度高于对照组（P<0.01）。实时SWE客观地确定了肝脏硬度变化的趋势，并无创地检测了非酒精性和酒精性脂肪性肝病进展过程中纤维化的发展。
