Department of Psychology, Graduate School of Letters, Kyoto University, Sakyo-ku, Kyoto, 606-8501 Japan ; Japan Society for the Promotion of Science, Tokyo, 102-0083 Japan.
Department of Psychology, Graduate School of Letters, Kyoto University, Sakyo-ku, Kyoto, 606-8501 Japan.
Cogn Neurodyn. 2014 Aug;8(4):345-51. doi: 10.1007/s11571-014-9284-2. Epub 2014 Mar 22.
We investigated the ability of rats to recall sequences of nose-poke holes with a modified serial reaction time task. In each trial, a sequence was randomly selected and the position of the first illuminated hole, which functioned as a cue stimulus, informed the rats whether the following sequence was a predictable one or not, based on prior training. The rats responded predictively only when the cues of the predictable sequences were presented. They did not show predictive responses when the cues of unpredictable sequences were presented, even though the unpredictable sequences partially had the same order of holes as the predictable sequences. These results indicate that the rats can recall sequences on the basis of presentation of the first cue stimulus informing predictable or unpredictable sequences. Recording neuronal activity while rats perform this behavioral task would be useful to elucidate neuronal mechanisms that mediate sequence recall.
我们使用改良的序列反应时任务，研究了大鼠回忆一系列触孔位置的能力。在每次试验中，随机选择一个序列，第一个被照亮的触孔的位置（作为提示刺激）会根据之前的训练告知大鼠，接下来的序列是可预测的还是不可预测的。只有当呈现可预测序列的提示时，大鼠才会做出预测性反应。即使不可预测序列的部分触孔顺序与可预测序列相同，大鼠也不会对不可预测序列的提示做出预测性反应。这些结果表明，大鼠可以根据提示刺激的呈现来回忆序列，提示刺激告知序列是可预测的还是不可预测的。在大鼠执行此行为任务时记录神经元活动，将有助于阐明介导序列回忆的神经元机制。
