Williams P J, Browne J L, Patel R A
University of the Pacific School of Pharmacy, Stockton, California.
Clin Pharmacokinet. 1989 Jul;17(1):45-52. doi: 10.2165/00003088-198917010-00004.
Twelve pharmacokinetic methods of estimating lithium maintenance dosage requirements were compared in 21 patients with bipolar illness. Methods which were compared included the single- and multiple-point methods of Perry, 4 non-linear regression and 6 Bayesian methods. The REVOL algorithm was employed for converging on to estimates of clearance and apparent volume of distribution for the non-linear regression and Bayesian methods. Data analysis was based on an evaluation of prediction error as a measure of bias, and absolute prediction error as a measure of precision. In a direct comparison, there were no statistically significant differences in bias or precision between any of the methods.
