Thomas Jefferson University, Jefferson Medical College, Jefferson Headache Center , 900 Walnut Street, Suite 200, Philadelphia, PA 19107 , USA +215 955 2243 ; +1 215 955 2060 ;
Expert Opin Pharmacother. 2014 Sep;15(13):1863-74. doi: 10.1517/14656566.2014.937704. Epub 2014 Jul 10.
Migraine is a common headache disorder that causes significant disability. COX inhibitors (also referred to as NSAIDs) are a frequently used treatment option.
A PubMed search provided articles relating to migraine and COX inhibitors. This article reviews the mechanism of action of NSAIDs in migraine, specifically the inhibition of COX isoenzymes and prostaglandin synthesis. Their central and peripheral effects are reviewed. The evidence for the use of NSAIDs in acute, preventive and rescue therapy, as well as other special circumstances, is discussed.
We use NSAIDs as first-line acute treatment for migraine in both out-patient and in-patient settings, as well as for preventive treatment in menstrual migraine. We also employ NSAIDS as a bridge therapy. We feel more research is needed to develop a greater variation of dosage forms for current NSAIDs as well as more combination therapies.
偏头痛是一种常见的头痛疾病，会导致严重的残疾。环氧化酶抑制剂（也称为 NSAIDs）是一种常用的治疗选择。
对 PubMed 搜索提供的与偏头痛和 COX 抑制剂相关的文章进行了综述。本文综述了 NSAIDs 在偏头痛中的作用机制，特别是对 COX 同工酶和前列腺素合成的抑制作用。还综述了它们的中枢和外周作用。讨论了 NSAIDs 在急性、预防性和抢救性治疗以及其他特殊情况下的应用证据。
我们在门诊和住院环境中使用 NSAIDs 作为偏头痛的一线急性治疗药物，也将其用于月经性偏头痛的预防性治疗。我们还将 NSAIDs 用作桥接治疗。我们认为，需要更多的研究来开发更多不同剂量形式的现有 NSAIDs 以及更多的联合治疗方法。
