Obradovic Milan M, Trpkovic Andreja, Bajic Vladan, Soskic Sanja, Jovanovic Aleksandra, Stanimirovic Julijana, Panic Milos, Isenovic Esma R
Clin Chem Lab Med. 2015 Jan;53(1):29-34. doi: 10.1515/cclm-2014-0590.
C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.
C反应蛋白（CRP）是一种炎症标志物。动脉粥样硬化现在被认为是一种炎症性疾病，而且似乎CRP直接促成动脉粥样硬化的形成。低密度脂蛋白（LDL）分子的氧化增加了巨噬细胞对脂质产物的摄取，导致胆固醇积累并随后形成泡沫细胞。血液中高敏CRP（hsCRP）和氧化型LDL（OxLDL）水平升高被发现与心血管疾病（CVD）相关。在本综述中，我们强调了CRP和OxLDL参与相互关联的（病理）生理途径的证据。还将总结临床环境中hsCRP与OxLDL之间关联的研究结果。
