Fanin R, Zuffa E, Fasola G, Damiani D, Gallizia C, Michieli M G, Marcuzzi P, Russo D, Visani G, Resegotti L
Haematologica. 1989 Mar-Apr;74(2):161-5.
Pretreatment serum total lactate dehydrogenase (LDH) activity was measured in 341 adult patients (greater than 15 years old) with acute lymphocytic leukemia (ALL) in order to assess its prognostic value. Failure, death during induction and remission were not related to LDH. In contrast, a negative and continuous relationship was found between LDH and relapse-free survival. Though LDH activity was significantly higher in cases with already established risk factors such as high WBC count, FAB L3 cytotype, mature B-cell phenotype, and central nervous system involvement, LDH was confirmed to be the strongest predictor of remission duration by multivariate analysis. This study provides a definitive confirmation of the negative prognostic value of LDH in adult ALL.
为评估预处理血清总乳酸脱氢酶（LDH）活性的预后价值，对341例成年（大于15岁）急性淋巴细胞白血病（ALL）患者进行了检测。诱导期失败、诱导期死亡及缓解情况均与LDH无关。相比之下，LDH与无复发生存期呈负相关且持续相关。虽然在已存在高危因素如高白细胞计数、FAB L3细胞类型、成熟B细胞表型及中枢神经系统受累的病例中LDH活性显著更高，但多因素分析证实LDH是缓解持续时间的最强预测指标。本研究明确证实了LDH在成人ALL中的不良预后价值。
