Wu Yumei, Zhang Zhou, Tao Liming, Chen Guoliang, Liu Fatao, Wang Ting, Xue Feng, Chen Yingwei, He Lin, Zheng Jie, Liu Yun
Department of Dermatology, Luwan Branch, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China.
Dermatology. 2014;229(2):70-5. doi: 10.1159/000360160. Epub 2014 Jul 10.
Copy number variations of FCGR3B are associated with several immune related diseases such as systemic lupus erythematosus, rheumatoid arthritis and primary Sjögren's syndrome. Little is known about the association between FCGR3B copy number variants and psoriasis.
To investigate whether FCGR3B copy number variants are associated with susceptibility to psoriasis vulgaris in the Chinese Han population.
343 psoriasis vulgaris patients and 574 healthy individuals were recruited as cases and controls. TaqMan® Copy Number Assays were performed to quantify the copy numbers in the FCGR3B locus. CopyCaller v1.0 software and R (version 2.15.3) were used to do the subsequent statistical analysis.
A significant association between psoriasis vulgaris and a high copy number (>2) of FCGR3B was observed (odds ratio = 1.63, 95% confidence interval 1.09-2.45, p < 0.02). However, the low copy number of FCGR3B was not significantly associated with psoriasis vulgaris.
A high copy number of FCGR3B is associated with psoriasis vulgaris in Han Chinese.
FCGR3B的拷贝数变异与多种免疫相关疾病有关，如系统性红斑狼疮、类风湿性关节炎和原发性干燥综合征。关于FCGR3B拷贝数变异与银屑病之间的关联知之甚少。
探讨FCGR3B拷贝数变异是否与中国汉族人群寻常型银屑病易感性相关。
招募343例寻常型银屑病患者和574名健康个体作为病例组和对照组。采用TaqMan®拷贝数分析法定量FCGR3B基因座中的拷贝数。使用CopyCaller v1.0软件和R（版本2.15.3）进行后续统计分析。
观察到寻常型银屑病与FCGR3B高拷贝数（>2）之间存在显著关联（比值比=1.63，95%置信区间1.09 - 2.45，p < 0.02）。然而，FCGR3B低拷贝数与寻常型银屑病无显著关联。
FCGR3B高拷贝数与中国汉族人群寻常型银屑病相关。
