Smyth E G, Stevens P J, Holliman R E
Department of Medical Microbiology, St. George's Hospital Medical School, London, UK.
J Antimicrob Chemother. 1989 Apr;23(4):633-9. doi: 10.1093/jac/23.4.633.
Combinations of aminoglycosides plus ampicillin usually are necessary for the satisfactory management of serious Enterococcus faecalis sepsis. A study in a South London hospital demonstrated that 7% of all E. faecalis, and 30% of those from blood cultures, were highly gentamicin resistant. Addition of gentamicin confers no benefit to the treatment of these organisms with ampicillin. We looked at the susceptibility pattern of these organisms in vitro and concluded that ampicillin plus ciprofloxacin offered the best available combination.
氨基糖苷类药物与氨苄西林联合使用通常是有效治疗严重粪肠球菌败血症所必需的。伦敦南部一家医院的一项研究表明，所有粪肠球菌中有7%，血培养分离出的粪肠球菌中有30%对庆大霉素高度耐药。对于用氨苄西林治疗这些细菌，添加庆大霉素并无益处。我们研究了这些细菌的体外药敏模式，得出氨苄西林加环丙沙星是最佳联合用药方案的结论。
