Dhinsa Baljinder S, Mahapatra Anant N, Khan Wasim S
Guy's and St Thomas' Hospital, Great Maze Pond, London SE1 9RT, England.
Curr Stem Cell Res Ther. 2015;10(1):26-30. doi: 10.2174/1574888x09666140710102808.
Tendon and ligament injuries are common, and repair slowly with reduced biomechanical properties. With increasing financial demands on the health service and patients to recover from tendon and ligament injuries faster, and with less morbidity, health professionals are exploring new treatment options. Tissue engineering may provide the answer, with its unlimited source of natural cells that in the correct environment may improve repair and regeneration of tendon and ligament tissue. Mesenchymal stem cells have demonstrated the ability to self renew and have multilineage differentiation potential. The use of bone marrow-derived mesenchymal stem cells has been reported, however significant in vitro culture expansion is required due to the low yield of cells, which has financial implications. Harvesting of bone marrow cells also has associated morbidity. Several studies have looked at alternative sources for mesenchymal stem cells. Reports in literature from animal studies have been encouraging, however further work is required. This review assesses the potential sources of mesenchymal stem cells for tissue engineering in tendons and ligaments.
肌腱和韧带损伤很常见，修复缓慢且生物力学性能降低。随着医疗服务在经济上的需求增加，以及患者需要更快地从肌腱和韧带损伤中恢复且发病率更低，医疗专业人员正在探索新的治疗选择。组织工程学或许能提供答案，其天然细胞来源不受限制，在合适的环境中可能改善肌腱和韧带组织的修复与再生。间充质干细胞已证明具有自我更新能力和多向分化潜能。已有报道使用骨髓来源的间充质干细胞，然而由于细胞产量低，需要进行大量的体外培养扩增，这涉及到费用问题。采集骨髓细胞也存在相关的发病率。一些研究已着眼于间充质干细胞的替代来源。动物研究的文献报道令人鼓舞，但仍需进一步研究。本综述评估了用于肌腱和韧带组织工程的间充质干细胞的潜在来源。
