Keskin D, Keskin G, Inal A, Ozışık L
Acta Clin Belg. 2014 Aug;69(4):246-50. doi: 10.1179/2295333714Y.0000000030.
Angiogenesis plays an important role in the pathogenesis of inflammatory diseases, but the possible role of angiogenesis in Behçet's disease (BD) has not yet been studied. The aim of this study was to determine angiostatin levels in patients with BD and the role of angiogenesis in the pathogenesis of the disease. Thirty-seven patients with BD (mean age: 28·6±5·4 years, mean disease duration: 9·3±3·7 years) and 18 healthy controls were enrolled to the study. Twenty-four patients were in active and 13 patients were in inactive stage of the disease. The mean serum angiostatin level of patients with BD was 113·9±53·2 and 60·7±20·1 ng/ml in healthy controls. The mean serum angiostatin level was 142·7±43·1 ng/ml in active and 86·9±15·5 ng/ml in inactive patients with BD. Serum angiostatin levels were significantly high in patients with BD compared with healthy controls (P<0·001) and it was significantly high in active patients compared with inactive patients with BD (P<0·001). In inactive patients with BD, serum angiostatin concentrations were found to be higher compared with healthy controls (P<0·01). In active BD patients, the mean serum angiostatin level was correlated with the deep vein thrombosis (r = 0·482, P = 0·05), uveitis (r = 0·582, P = 0·01), and arthritis (r = 0·492, P = 0·05). According to these results; elevated serum angiostatin levels in patients with BD suggest the possible role of angiogenesis in the pathogenesis of the disease and its high levels in inactive Behçet's patients is related with the continuous activation of the disease even in the subclinical period.
血管生成在炎症性疾病的发病机制中起重要作用，但血管生成在白塞病（BD）中的可能作用尚未得到研究。本研究的目的是确定BD患者的血管抑素水平以及血管生成在该疾病发病机制中的作用。37例BD患者（平均年龄：28.6±5.4岁，平均病程：9.3±3.7年）和18名健康对照者纳入本研究。24例患者处于疾病活动期，13例患者处于非活动期。BD患者的平均血清血管抑素水平为113.9±53.2 ng/ml，健康对照者为60.7±20.1 ng/ml。BD活动期患者的平均血清血管抑素水平为142.7±43.1 ng/ml，非活动期患者为86.9±15.5 ng/ml。与健康对照者相比，BD患者的血清血管抑素水平显著升高（P<0.001），与BD非活动期患者相比，活动期患者的血清血管抑素水平显著升高（P<0.001）。在BD非活动期患者中，血清血管抑素浓度高于健康对照者（P<0.01）。在BD活动期患者中，平均血清血管抑素水平与深静脉血栓形成（r = 0.482，P = 0.05）、葡萄膜炎（r = 0.582，P = 0.01）和关节炎（r = 0.492，P = 0.05）相关。根据这些结果；BD患者血清血管抑素水平升高提示血管生成在该疾病发病机制中可能起作用，且在BD非活动期患者中其高水平与疾病即使在亚临床期仍持续激活有关。
