Üçok Alp, Kıvrak Tihan Aysu, Karadayı Gülşah, Tükel Raşit
Department of Psychiatry, Faculty of Medicine, Istanbul University , Istanbul , Turkey.
Int J Psychiatry Clin Pract. 2014 Oct;18(4):243-7. doi: 10.3109/13651501.2014.943243. Epub 2014 Aug 26.
The aim of this study is to investigate the effects of obsessive-compulsive symptoms (OCS) on quality of life (QoL) and to identify the OCS with a particular effect on QoL, and whether there are any such symptoms for patients with schizophrenia.
We studied three groups of patients with schizophrenia. One group of patients (n = 45) without OCS or obsessive-compulsive disorder (OCD), one group with OCS, not fulfilling the diagnostic criteria for OCD (n = 31), and one group with OCD as a comorbid condition (n = 24). Severity of clinical symptoms was evaluated with the Positive and Negative Symptom Scale and OCS was examined using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Symptom Checklist. We also administered the Y-BOCS. The patients' QoL was assessed using the Quality of Life Scale (QLS).
QLS interpersonal relationships subscale scores of those with OCS were lower than those without OCS. There was no difference among OCS, non-OCS, and OCD groups in terms of QoL. There was no relationship between QLS scores and symmetry, contamination and causing harm obsessions, but those with cleaning and repeating compulsions had lower QoL.
Questioning of comorbid OCS and treatment with specific medication in schizophrenia patients may increase QoL.
本研究旨在调查强迫症状（OCS）对生活质量（QoL）的影响，确定对生活质量有特定影响的强迫症状，以及精神分裂症患者是否存在此类症状。
我们研究了三组精神分裂症患者。一组患者（n = 45）无强迫症状或强迫症（OCD），一组有强迫症状但不符合强迫症诊断标准（n = 31），一组有强迫症合并症（n = 24）。使用阳性和阴性症状量表评估临床症状的严重程度，并使用耶鲁-布朗强迫量表（Y-BOCS）症状清单检查强迫症状。我们还使用了Y-BOCS。使用生活质量量表（QLS）评估患者的生活质量。
有强迫症状患者的QLS人际关系子量表得分低于无强迫症状患者。在生活质量方面，强迫症状组、无强迫症状组和强迫症组之间没有差异。QLS得分与对称性、污染和造成伤害的强迫观念之间没有关系，但有清洁和重复强迫行为的患者生活质量较低。
对精神分裂症患者合并的强迫症状进行询问并使用特定药物治疗可能会提高生活质量。
