Department of Cardiology, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark
Department of Cardiology, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark.
Europace. 2015 Jan;17(1):117-22. doi: 10.1093/europace/euu176. Epub 2014 Jul 10.
To assess the long-term mortality and occurrence of post-ablation atrial fibrillation in patients undergoing a radiofrequency ablation for the Wolff-Parkinson-White (WPW) syndrome.
A retrospective cohort study of patients (N = 362) subjected to radiofrequency ablation of the WPW syndrome at Aarhus University Hospital from 1990 to 2011. A comparison cohort (N = 3619) was generated from the Danish National Board of Health Central Population Registry. We found no significant difference in all-cause mortality when comparing the WPW group with the control group [hazard ratio (HR): 0.77 and confidence interval (CI): 0.47-1.25]. After radiofrequency ablation, the WPW group had a significantly higher risk of atrial fibrillation than the control group (HR: 4.77 and CI: 3.05-7.43). Atrial fibrillation prior to ablation (HR: 4.66 and CI: 2.09-10.41) and age over 50 years (HR: 9.79 and CI: 4.29-22.36) at the time of ablation were independent risk factors for post-ablation atrial fibrillation in the WPW group.
Patients with radiofrequency ablation-treated WPW syndrome have a post-ablation mortality that is similar to the background population. The risk of atrial fibrillation remains high after radiofrequency ablation of the WPW syndrome.
评估射频消融治疗 Wolff-Parkinson-White（WPW）综合征患者的长期死亡率和消融后心房颤动的发生情况。
对 1990 年至 2011 年在奥胡斯大学医院接受 WPW 综合征射频消融的患者（N=362）进行回顾性队列研究。从丹麦国家卫生局中央人口登记处生成了一个对照队列（N=3619）。与对照组相比，WPW 组的全因死亡率无显著差异[风险比（HR）：0.77，置信区间（CI）：0.47-1.25]。射频消融后，WPW 组的心房颤动风险明显高于对照组（HR：4.77，CI：3.05-7.43）。消融前的心房颤动（HR：4.66，CI：2.09-10.41）和消融时年龄超过 50 岁（HR：9.79，CI：4.29-22.36）是 WPW 组消融后发生心房颤动的独立危险因素。
接受射频消融治疗的 WPW 综合征患者的消融后死亡率与背景人群相似。WPW 综合征射频消融后心房颤动的风险仍然很高。
