伊朗小儿肝移植受者移植六个月后念珠菌感染情况评估。
Evaluation of Candida infection after six months of transplantation in pediatric liver recipients in iran.
作者信息
Honar N, Imanieh M H, Haghighat M, Dehghani S M, Zahmatkeshan M, Geramizadeh B, Badiee P, Nikeghbalian S, Kazemi K, Bahador A, Salahi H, Malek-Hosseini S A
机构信息
Gastroenterohepatology Research Center.
Gastroenterohepatology Research Center, ; Shiraz Transplant Research Center.
出版信息
Int J Organ Transplant Med. 2011;2(3):105-7.
BACKGROUND
Liver transplantation (LT) is the standard treatment of end-stage liver diseases (ESLD). Invasive fungal infection is one of the important causes of morbidity and mortality after transplantation.
OBJECTIVE
To determine the incidence of late-onset (after 6 months of LT) Candida infection in recipients.
METHODS
A retrospective study was conducted to evaluate 50 pediatric patients after LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We followed the patients until 6 months post-LT for episodes of Candida infection proven by culture.
RESULTS
One recipient (2%) developed late-onset esophageal candidiasis with improvement after intravenous amphotricin therapy but finally expired with a diagnosis of post-transplant lymphoproliferative disorder (PTLD).
CONCLUSIONS
The incidence of late-onset Candida infection is not significant in pediatric liver recipient, but it still remains a significant problem. Control of Candida colonization would reduce the risk of invasive fungal infections and possibly more fatal complications.
背景
肝移植（LT）是终末期肝病（ESLD）的标准治疗方法。侵袭性真菌感染是移植后发病和死亡的重要原因之一。
目的
确定肝移植受者中迟发性（肝移植6个月后）念珠菌感染的发生率。
方法
进行一项回顾性研究，对伊朗设拉子医科大学附属内马齐医院肝移植科8年间接受肝移植的50例儿科患者进行评估。我们对患者进行随访，直至肝移植后6个月，以观察经培养证实的念珠菌感染发作情况。
结果
1例受者（2%）发生迟发性食管念珠菌病，静脉注射两性霉素治疗后病情改善，但最终因移植后淋巴组织增生性疾病（PTLD）诊断而死亡。
结论
儿科肝移植受者中迟发性念珠菌感染的发生率不高，但仍是一个重大问题。控制念珠菌定植将降低侵袭性真菌感染的风险以及可能出现的更多致命并发症的风险。
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