Cook Robert L, Thompson Erika L, Kelso Natalie E, Friary John, Hosford Jennifer, Barkley Phillip, Dodd Virginia J, Abrahamsen Martha, Ajinkya Shaun, Obesso Peter Daniel, Rashid Mohammed H, Giuliano Anna R
From the *Departments of Epidemiology and †Medicine, ‡Student Healthcare Center, §Department of Community Dentistry & Behavioral Science, and ¶Emerging Pathogens Institute, University of Florida, Gainesville, FL; and ∥Center for Infection Research in Cancer (CIRC), Moffitt Cancer Center, Tampa, FL.
Sex Transm Dis. 2014 Aug;41(8):486-92. doi: 10.1097/OLQ.0000000000000159.
Oral human papillomavirus (HPV) is associated with a rising incidence of certain head and neck cancers, and oral sex has been associated with oral HPV. This study sought to identify more specific patterns of oral sexual activity, including self-inoculation, that are associated with oral HPV infections in young women.
A total of 1010 women attending a large university completed a computer-based questionnaire and provided oral specimens that were tested for any oral HPV using a Linear Array assay that detects any HPV as well as 37 HPV genotypes. Twenty-seven women provided additional samples up to 12 months after enrollment. Bivariable and multivariable analyses were conducted to identify oral sexual patterns and other risk factors associated with prevalent oral HPV.
Nineteen women had prevalent oral HPV (1.9%), with 10 women (1%) having a type-specific infection. Oral HPV was significantly associated with lifetime coital sex partnership numbers (P = 0.03), lifetime and yearly oral sex partnership numbers (P < 0.01), and hand and/or sex toy transfer from genitals to mouth (P < 0.001). Oral HPV was also associated with greater use of alcohol, cigarettes, marijuana, and sharing of smoking devices, lipstick, or toothbrushes (P < 0.05 for each), with an apparent dose-response for alcohol use and smoking behavior, stratified by number of sexual partners. Of 7 women with prevalent HPV who provided follow-up samples, none had evidence of a persistent type-specific infection.
These data provide additional evidence of transmission of oral HPV from oral sexual activity and also suggest possible transmission from self-inoculation or sharing of oral products.
口腔人乳头瘤病毒（HPV）与某些头颈癌发病率的上升有关，而口交与口腔HPV感染相关。本研究旨在确定更具体的口交行为模式，包括自我接种，这些模式与年轻女性的口腔HPV感染有关。
一所大型大学的1010名女性完成了一份基于计算机的问卷，并提供了口腔样本，使用线性阵列检测法检测样本中是否存在任何口腔HPV以及37种HPV基因型。27名女性在入组后12个月内提供了额外样本。进行了双变量和多变量分析，以确定与口腔HPV感染相关的口交模式和其他风险因素。
19名女性存在口腔HPV感染（1.9%），其中10名女性（1%）为特定类型感染。口腔HPV感染与终身性交性伴侣数量（P = 0.03）、终身和每年口交性伴侣数量（P < 0.01）以及手和/或性玩具从生殖器转移至口腔显著相关（P < 0.001）。口腔HPV感染还与更多地使用酒精、香烟、大麻以及共用吸烟器具、口红或牙刷有关（每项P < 0.05），按性伴侣数量分层后，酒精使用和吸烟行为存在明显的剂量反应关系。在提供随访样本的7名HPV感染女性中，无人有持续特定类型感染的证据。
这些数据为口腔HPV通过口交行为传播提供了更多证据，也提示了可能通过自我接种或共用口腔用品传播。
